MMP1 and MMP20 contribute to tooth agenesis in humans
نویسندگان
چکیده
منابع مشابه
Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis.
Tooth agenesis in human being is the most common congenital anomaly associated with dental development. Mutations in many genes such as MSH homeobox 1 (MSX1), paired box gene 9 (PAX9), ectodysplasin A (EDA) and EDA receptor (EDAR) have been associated with familial form of this condition. However, in large majority of patients, genetic cause could not be identified. The primary aim of present s...
متن کاملGenetic variations in MMP9 and MMP13 contribute to tooth agenesis in a Brazilian population.
We investigated the association between polymorphisms in the MMP2 (rs243865), MMP9 (rs17576), and MMP13 (rs2252070) genes with tooth agenesis in humans. Two hundred eighty-five unrelated individuals (202 controls without tooth agenesis and 83 cases with tooth agenesis) were evaluated in a cross-sectional single-center study. The study participants were recruited through the Pediatric Dental Cli...
متن کاملTooth Agenesis
Tooth agenesis denotes a condition where teeth are missing due to a developmental failure. According to severity, this malformation can be subdivided into hypodontia, oligodontia and anodontia. With a frequency of 20–30%, tooth agenesis is the most prevalent dental dysplasia, but not all teeth are equally affected. Familial occurrence and concordance in twins indicate potential genetic causes. ...
متن کاملRadiographic Evaluation of Dental Development in Patients With Tooth Agenesis
Introduction: Hypodontia is one of the most common developmental anomalies. This study aimed to evaluate the variations of radiographic dental development in a group of Iranian children with dental agenesis. Materials and Methods: This study evaluated 1230 Orthopantomographs (OPGs) for agenesis of permanent teeth obtained from the patients aged between 8 and 18 years. Then the difference betwe...
متن کاملColorectal cancer and self-reported tooth agenesis
BACKGROUND Germline mutations in APC and AXIN2 are both associated with colon neoplasia as well as anomalous dental development. We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis. METHODS Via a survey conducted on 1636 individuals with colorectal cancer (CRC) and 2788 indi...
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ژورنال
عنوان ژورنال: Archives of Oral Biology
سال: 2011
ISSN: 0003-9969
DOI: 10.1016/j.archoralbio.2010.11.007